Education
Neurosurgical Residency, Dept. of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 7/02-Present
M.D., Medical College of Wisconsin, Milwaukee, WI 8/98-5/02
Ph.D., Dept. of Cell. Biology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 6/90-6/96
B.S., University of Texas at El Paso, El Paso, TX 6/87-5/90
Undergraduate, St. Mary's University, San Antonio, TX 6/85-5/87
Positions Held
Postdoctoral Fellow, Dept. of Neurosurgery, MCW, Milwaukee, WI 7/96-9/99
NASA Payload Specialist, Kennedy Space Center, Coco Beach, FL. and Moffett Field, Palo Alto, CA 7/90-6/96
Eye Bank Technical Specialist, Wisconsin Lion's Eye Bank Alto, CA 6/91-8/93
Undergraduate Research Fellow, Cold Spring Harbor Laboratory, CSH, Long Island, NY 5/88-8/88
Dissertation For my dissertation entitled, “Temporal and morphological analysis of myelinated sensory and motor axons in post-axotomized peripheral nerves of adult rats,” I developed a basic science animal model to address confounding clinical issues regarding the timing and location of peripheral nerve repair. The discriminate responses of motor and sensory axons following axotomy and their distribution within a neuroma were investigated. My overall findings suggest that both inherent differences in the injury response between myelinated sensory and motor axons and distance from cell body to injury site are significant factors in regeneration. Regenerating motor axons were shown to lag considerably compared to their regenerating sensory axons. Neuroma analysis revealed a dynamic structure whose composition and distribution of motor and sensory axons changed with time. Combined, these results provide insight to peripheral nerve regeneration that may facilitate and guide the timing of nerve repair.
During my doctoral work, I served as a payload specialist with NASA. I participated both in NASA’s space life sciences missions (SLS-1 and SLS-2) and several international pilot studies. The two missions, launched on the space shuttle Columbia, contained experiments designed to study the effects of antigravity and re-entry forces on the musculoskeletal and nervous systems.
Current Clinical Interests I have been very fortunate to have had a rigorous training focused on complex degenerative and traumatic spine diseases and disorders. As such, my surgical strengths are in but not limited to the treatment of complex and degenerative spine disease with and without instrumentation. Additionally, my exposure to cranial and general neurosurgical conditions has been comprehensive and I do not envision a career limited to spine but rather, desire a practice treating general adult neurosurgical conditions. I am convinced that my strengths, temperament and commitment to appropriate and passionate patient care correlate to pursing a private practice career; and will specifically afford me the ability to contribute to a thriving practice.
Academic Awards
Resident Travel Award for 11th International Symposium on Neural Regeneration 12/05
Department of Neurosurgery Medical School Scholarship 9/98-7/02
American Association of Anatomists Travel Award 2/95
Three Department of Cellular Biology and Anatomy Travel Awards to Soc. for Neuroscience, Federation of American Societies for Experimental Biology and Midwest Neurobiologists National Meetings 93-94
Graduate Division Fellowship, Medical College of Wisconsin 7/90-6/96
Research Grants
Bryon Riesch Paralysis Foundation Research Grant Award 2/06-2/07
American Paraplegia Society Research Grant Award 12/99-3/01
Academic Committees
MCWAH Internal Review Committee of the Neurology Residency Program 12/06
Membership in Professional Societies
Wisconsin Medical Society 02-Present
AANS/CNS—Resident Member 02-Present
American Medical Association 98-Present
MCW Surgical Interest Group /Secretary and Principle Fundraiser 99-2000
Society for Neuroscience 93-99
Graduate Student Association /Dept. Rep and President 92-95
Lectureships
Junior Medical Student Lecture—Spine and Spinal Cord Surgical Pathologies/Conditions 2-6/09
Brain Dissection and Neuroscience: Applications to Disorders of Language and Speech Functions,
Marquette University, Milwaukee, WI 7/07; 8/05
Brain and Spinal Cord Dissection Course, Marquette University, Milwaukee, WI 7/05
12th International Conference on Mathematical & Computer Modeling & Scientific Computing Lecture,
Chicago, IL. 5/99
Advanced Cellular and Molecular Neurobiology Course Lecturer, MCW, Milwaukee, WI 11/98
Annual Faculty Conference Invitation by the North American Spine Society, New York, N.Y. 11/97
Royal Netherlands Academy of Sciences, 20th Intl. Brain Research Summer School; Amsterdam,
Holland 8/97
Brain Awareness Week, MCW, Milwaukee, WI 3/97
Interests
Milwaukee Art Museum Member 5/05-Present
Medical Student Volunteer with MEDICO medical mission to Honduras, Central America 7/99
Leukemia Society Marathon, Anchorage, AK. 6/97
MACC Fund TREK-100/ American Cancer Society for Breast Cancer/ Race for a Cure for Diabetes Cycling
Publications
Chapters
1. Macias M.Y., and Wolfa C. Biomechanical Considerations for Early Operative Interventions in Vertebral Column Fractures and Dislocation. Neurosurgical Emergencies 2nd Edition. ed. Christopher Loftus., Thieme Publ., pp. 222-232; 2008.
2. Macias M.Y., and Maiman D.J. Critical Care of Acute Spinal Cord Injury. Neurotrauma and Critical Care of the Spine. eds. Jack Jallo and Alexander Vaccaro, New York, NY., Thieme Publ., pp. 171-194; 2009.
3. Macias M.Y., and Maiman D.J. Spinal Cord Injury. Neurocritical Care: A Practical Guide. ed. Michael T. Torbey,
New York, NY, Cambridge Univ. Press. (in press)
Abstracts
1. Riley, D.A., S. Ellis, G.R. Slocum, F.R. Sedlak, J.L.W. Bain, B.B. Krippendorf, M.Y. Macias, and J.L. Thompson: Spaceflight and reloading effects on rat hindlimb. Amer. Soc. Gravit. Space Biol. 7:81, 1993.
2. Riley, D.A., S. Ellis, G.R. Slocum, F.R. Sedlak, J.L.W. Bain, B.B. Krippendorf, M.Y. Macias, and J.L. Thompson: Spaceflight and reloading effects on rat hindlimb skeletal muscles. Amer. Soc. Gravit. Space Biol. 7:81, 1993.
3. Riley, D.A., S. Ellis, G.R. Slocum, F.R. Sedlak, J.L.W. Bain, C.T. Lehman, M.Y. Macias, J.L. Thompson, K. Vijayan, and J.A. DeBruin: SLS2 inflight and postflight changes in skeletal muscles of 14-day-spaceflown rats. Amer. Soc. Gravit. Space Biol. 8:85, 1994.
4. Riley, D.A., J.R. Sanger, N.J. Yousiff, H.S. Matloub, M.Y. Macias and J.L.W. Bain. Histochemically-aided microsurgical repair of injured human peripheral nerves. Amer. Inst. Aero. Astro. 1995.
5. Macias, M.Y., D.A. Riley. Temporal and morphological analysis of motor and sensory axons in post-axotomized peripheral nerves of rats. FASEB Journal 9:3,1995.
6. Macias, M.Y., D.A. Riley and C.T. Lehman: Histochemical analysis of sensory and motor axons and neuronal cell bodies following axotomy of the median-ulnar and sciatic nerves of adult rats. Society for Neuroscience Abstracts 21:3, 1995.
7. Wilke, R.A., M.Y. Macias and S. Salisbury: Fibrotic changes in the adrenal medullae of diabetic BB/W rats known to have impaired catecholamine secretion. American College of Physicians Wisconsin Chapter and Society of Internal Medicine, 1996.
8. Macias, M.Y., J.H. Battocletti, F.A. Pintar and D.J. Maiman: Linear pulsed electromagnetic fields (PEMF) induce directional neurite outgrowth from mammalian DRG in vitro. 20th International Summer School of Brain Research, Royal Netherlands Academy of Arts and Sciences, 1997.
9. Macias, M.Y. and J.H. Battocletti: Asymmetrical neurite outgrowth following pulsed electromagnetic stimulation in vitro. North American Spine Society Meeting Abstracts, 1997.
10. Macias, M.Y., J.H. Battocletti, F.A. Pintar and D.J. Maiman: Directional Neurite Outgrowth following linear pulsed electromagnetic field (PEMF) stimulation. Society for Neuroscience Abstracts, 1997.
11. Macias, M.Y., J.H. Battocletti, F.A. Pintar and D.J. Maiman: Effects of linear pulsed electromagnetic fields (PEMF) on single-cell sensory and motor protein expression profiles. Seventh International Symposium on Neural Regeneration, Vol. 23 1997.
12. Crowe, M.J., M.Y. Macias, Z.P. Sun, F.A. Pintar, J.H. Battocletti and DJ Maiman: Use of non-invasive pulsed magnetic fields after spinal cord injury in cats. 18th Annual Neurotrauma Society Symposium Abstracts. 2000.
13. Crowe, M.J., Sun, Z.P., M.Y Macias, D.J. Maiman, F.A. Pintar, and J.H. Battocletti.: Changes in protein expression in spinal neuronal cultures subjected to pulsed magnetic field stimulation. Cervical Spine Research Society 30th Annual Meeting, Miami Beach, FL. 2002.
14. Maiman D.J., Z.P. Sun., J.H. Battocletti, M.Y. Macias, F.A. Pintar, and M.J. Crowe: Exposure to pulsed magnetic fields enhances motor recovery in cats following spinal cord injury. Cervical Spine Research Society 30th Annual Meeting, Miami Beach, FL. 2002.
15. Crowe M.J., Z.P. Sun, M.Y. Macias, D.J. Maiman, F.A. Pintar, and J.H. Battocletti: Analysis of protein expression in spinal neuronal cultures subjected to pulsed magnetic field stimulation. 9th International Symposium on Neural Regeneration, Monterey, CA, #P44. 2001.
16. Crowe M.J., M.Y. Macias, Z.P. Sun Z, F.A. Pintar, J.H. Battocletti, and D.J. Maiman:J: Use of non-invasive pulsed magnetic fields after spinal cord injury in cats. J Neurotrauma 17: 988. 2000.
17. Macias M.Y., Bacon M., and S.N. Kurpad: CGRP and GAP43 increase and colocalize in allodynic rats following SCI and stem cell transplantation. 11th International Symposium on Neural Regeneration, Monterey, CA. 2005.
18. Macias M.Y., Syring M.B., McHugh J., Svendsen C., and S.N. Kurpad: Absence of allodynia following neural stem cell transplantation into the injured spinal cord. 24th Annual Neurotrauma Society Symposium, St. Louis, MO. 2006.
19. Macias M.Y., Bacon M.B., McHugh J., Svendsen C., and S.N. Kurpad: Lack of allodynic responses following astrocyte deficient human neural stem cell transplantation, CNS Annual Meeting, Chicago, Ill. 2006.
20. Macias, M.Y., Bacon M., Rickert K., Alexanian A., and S.N. Kurpad: thermal allodynia following C17.2 and C17.2/GDNF neural stem cell transplantation in spinal cord injury. AANS Annual Meeting, San Fransisco, CA. 2006.
Papers
1. Macias, M.Y., W.C. Herndon, and I. Agranat. Thermodynamic properties of the arene epoxides and the relative carcinogenicities of benzo[a]pyrene and benzo[e]pyrene. Polycyclic Aromatic Compounds, vol. 3(3), 199-207, 1993.
2. Riley, D.A., S. Ellis, G.R. Slocum, F.R. Sedlak, J.L.W. Bain, B.B. Krippendorf, C.T. Lehman, M.Y. Macias, J.L. Thompson, K. Vijayan and J.A. DeBruin. Inflight and postflight changes in skeletal muscles of SLS-1 and SLS-2 spaceflown rats. J. of Applied Physiology, 81 (1), 133-144, 1995.
3. Macias, M.Y., C.T. Lehman, J.R. Sanger and D.A. Riley. Myelinated sensory and alpha motor axon regeneration in peripheral nerve neuromas. Muscle & Nerve, 21, 1748-1758, 1998.
4. Battocletti, J.H., M.Y. Macias, F.A. Pintar, D.J. Maiman and C.H. Sutton. A box coil for the stimulation of biological tissue and cells in vitro and in vivo by pulsed magnetic fields. IEEE Transactions on Biomedical Engineering, 47 (3), 402-408, 2000.
5. Macias, M.Y., J.H. Battocletti, F.A. Pintar and D.J. Maiman: Directed and enhanced neurite growth with linear pulsed magnetic field (PMF) stimulation. Bioelectromagnetics, 21:272-286, 2000.
6. Kumaresan, S., N. Yoganandan, F.A. Pintar, M.Y. Macias, and J.F. Cusick: Morphology of young and old cervical spine intervertebral disc tissues. Biomedical Sciences Instrumentation, 36:141-6, 2000.
7. Crowe M.J., Z.P. Sun, M.Y. Macias, J.H. Battocletti, F.A. Pintar, and D.J. Maiman: Exposure to pulsed magnetic fields enhances motor recovery in cats following acute spinal cord injury. Spine, 28(24):2660-6, 2003.
8. Macias M.Y., M.B. Syring, M.A. Pizzi, M.J. Crowe, A.R. Alexanian and S.N. Kurpad. Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. Exp. Neurology, 201(2):335-348, 2006.
9. Macias, M.Y., G.S. Miranpuri, D.K. Resnick, and S.N. Kurpad. Post SCI allodynic peak expression of vanilloid-1, bradykinin-1 and -2 receptor mRNA following NSC transplantation. J Neurotrauma (submitted).
